Technology offer : Liposomes: an innovative system for vaccination

Technology's description

DNA Vaccination  of fish is a promising technology in aquaculture in order to prevent the diseases with strong economic impact (IHNV, VHSV, etc…).

In the current protocols,the most commonly practised route of administration of the vaccine is the intramuscular injection (i.m.) what generates strong economic and technical constraints related to the handling of the animals (equipment, personnel, partial loss  of production).

Other methods, easier to implement and less stressing for the animals were thus considered such as the administration by transcutaneous way (immersion) or by oral way.

Based on the capacities of cationic liposomes to vectorize nucleic acids, and on the properties of bioadhesion of alginate, the CIRAD developed a system of delivery for DNA vaccination  of fish by transcutaneous or oral way.


  • Easy to product
  • Low toxicity
  • Biocompatible and biodegradable
  • Bioadhesive properties
  • Avoid the handling of animals
  • Synthetic system with low production cost
  • Independancy between vector and the coding genetic sequence
  • Stability
Ref : OT-00012

Area of activity : HEALTH COSMETOLOGY

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Industrial applications

  • Oral vaccination of animals

Intellectual property

  • Patented technology

Technology transfer

  • Know-how
  • License


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