Technology offer : Liposomes: an innovative system for vaccination
DNA Vaccination of fish is a promising technology in aquaculture in order to prevent the diseases with strong economic impact (IHNV, VHSV, etc…).
In the current protocols,the most commonly practised route of administration of the vaccine is the intramuscular injection (i.m.) what generates strong economic and technical constraints related to the handling of the animals (equipment, personnel, partial loss of production).
Other methods, easier to implement and less stressing for the animals were thus considered such as the administration by transcutaneous way (immersion) or by oral way.
Based on the capacities of cationic liposomes to vectorize nucleic acids, and on the properties of bioadhesion of alginate, the CIRAD developed a system of delivery for DNA vaccination of fish by transcutaneous or oral way.